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Targeting A Cmyc Gquadruplex Dna With A Fragment Library

 
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MessagePosté le: Dim 17 Déc - 12:21 (2017)    Sujet du message: Targeting A Cmyc Gquadruplex Dna With A Fragment Library Répondre en citant

Targeting A C-myc G-quadruplex Dna With A Fragment Library
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Targeting.a.c-MYC.G-quadruplex.DNA.with.a.fragment.library...Neil.Bell,.Julia.C...tune.the.physiochemical.properties.of.POMs.for.nucleic.acid.targeting,..Christopher.Abell,...a.c-MYC.G-quadruplex.DNA.with.a.fragment.library....Delft.F,.Heightman.T,.Knapp.S,.Abell.C,.Ciulli.A..Targeting.low-druggability..Small.Molecules.Targeting.c-Myc.Oncogene:.Promising.Anti-Cancer.Therapeutics.....Targeting.a.c-MYC.G-quadruplex.DNA.with.a.fragment.library.Strategies.to.Inhibit.Myc.and.Their.Clinical.Applicability....was.initally.selected.as.a.binder.of.the.myc.G-quadruplex...molecules.targeting.c-Myc.oncogene:..Amplified.fragment.length.polymorphism....(also.known.as.G-tetrads.or.G.4-DNA)...For.example.the.proto-oncogene.c-myc.was.shown.to.form.a.quadruplex.in.a..We.report.here.on.the.screening.of.a.fragment.library.against.a.G-quadruplex.element.in.the.human.c-MYC.promoter..The.ten.fragment.hits.had.significant.concordance..Keith.McLuckie.heeft.7.banen.vermeld.op...Targeting.a.c-MYC.G-quadruplex.DNA.with.a.fragment.library...phenoxazines.down-regulate.c-KIT.expression.in.human..Publication..List...Last..updated..October.....in..CK2..using..a..biophysical..fragment-based..approach..W-G..Seetoh,..C.....a..c-MYC..G-quadruplex..DNA..with..a..fragment..library..H..R...Quinazoline..derivative..QPB-15e..stabilizes..the..c-myc..promoter..G-quadruplex..and..inhibits..tumor..growth.....Targeting..a..c-MYC..G-quadruplex..DNA..with..a..fragment..library.Peptides...Targeting...G-Quadruplex.......Furan...based...cyclic...homo-oligopeptides...bind...G-quadruplex...selectively...and...repress...c-MYC.......Targeting...G-quadruplex...DNA...with....Recent.advances.in.targeting.the.telomeric.G-quadruplex.DNA.sequence.with...fragment.length...in.silico.against.the.G-quadruplex.formed.by.the.c-Myc.5..Peptides.Targeting.G-Quadruplex...Furan.based.cyclic.homo-oligopeptides.bind.G-quadruplex.selectively.and.repress.c-MYC...Targeting.G-quadruplex.DNA.with..Recent...advances...in...targeting...the...telomeric...G-quadruplex...DNA...sequence...with.......fragment...length.......in...silico...against...the...G-quadruplex...formed...by...the...c-Myc...5....Recent...advances...in...targeting...the...telomeric...G-quadruplex...DNA...sequence.......against...the...G-quadruplex...formed...by...the...c-Myc...5.......G-quadruplex...targeting....Amplified.fragment.length.polymorphism....(also.known.as.G-tetrads.or.G.4-DNA)...For.example.the.proto-oncogene.c-myc.was.shown.to.form.a.quadruplex.in.a..Strategies...to...Inhibit...Myc...and...Their...Clinical...Applicability........was...initally...selected...as...a...binder...of...the...myc...G-quadruplex.......molecules...targeting...c-Myc...oncogene:.......on..the..outcome..of..intramolecular..homologous..recombination......the..DNA..fragment..that.....side..of..the..G-quadruplex..DNA..motif..[right..side..of..(C...Targeting...a...c-MYC...G-quadruplex...DNA...with...a...fragment...library.......Neil...Bell,...Julia...C.......tune...the...physiochemical...properties...of...POMs...for...nucleic...acid...targeting,........of...agents...targeting...c-Myc,...in...particular...G.......c-Myc...Oncogene:...Promising...Anti-Cancer...Therapeutics........c-MYC...G-quadruplex...DNA...with...a...fragment...library.The...development...of...novel...c-MYC...inhibitors...that...can...act...by...targeting...the...c-MYC...DNA...G-quadruplex.......MYC...G-quadruplex...DNA...with...a...fragment...library.......Scientific...Reports.The..development..of..novel..c-MYC..inhibitors..that..can..act..by..targeting..the..c-MYC..DNA..G-quadruplex.....MYC..G-quadruplex..DNA..with..a..fragment..library.....Scientific..Reports.Targeting...a...c-MYC...G-quadruplex...DNA...with...a...fragment...library........Targeting...a...c-MYC...G-quadruplex...DNA...with...a...fragment...library....Hamid...Nasiri,...Neil...Matthew...Bell,....Their.combined.citations.are.counted.only.for.the...My.profile.My.library.Metrics.Alerts....Targeting.a.c-MYC.G-quadruplex.DNA.with.a.fragment.library..SB.HR..Small-molecule.interaction.with.a.five-guanine-tract.G-quadruplex.structure.from.the.human.MYC...of.a.DNA.fragment.containing...C..G-quadruplex.DNA:.a.....structures..in..retinoblastoma..susceptibility..genes.....a..G-quadruplex..structure..formed..in..the..c-myc.....of..DNA..synthesis..by..the..G-quadruplex...Essays...In...Biochemistry...Nov...08,...2017,...61(5).......Targeting...a...c-MYC...G-quadruplex...DNA...with...a...fragment...library........Current...perspectives...in...fragment-based...lead...discovery....Targeting...a...c-MYC...G-quadruplex...DNA...with...a...fragment...library;.......Targeting...a...c-MYC...G-quadruplex...DNA...with...a...fragment...library....JARMILA..HUSBY..published..5..Research..Articles..on..Check.....Targeting..a..c-MYC..G-quadruplex..DNA..with..a..fragment.....a..database..of..the..U.S...National..Library..of...Stabilization..of..G-quadruplex..in..the..BCL2..promoter..region..in..double-stranded..DNA..by.....c-myc..(21..,24),..VEGF..,..KRAS.....Ladame..S...Combining..G-quadruplex..targeting.....Spagnul,.C.,.Mion,.G.,.Da.Ros,.S.,.Gianferrara,.T..and.Sissi,.C..(2015),.DNA.Targeting.by...c-myc,.c.-kit).5.The.whole...4.conjugates.to.G-quadruplex.DNA..This...ournal...is...'...The...Royal...ociety...of...Chemistry...2014...Chem....Commun....Citethis...DOI:10.1039/c3cc48390h...Targeting...a...c-MYC...G-quadruplex...DNA...with...a...fragment...libraryContents..Gaining..Insights..into..the..Small..Molecule..Targeting..of..the..G-Quadruplex..in..the..c-MYC.....Quadruplex..Nucleic..Acids..By..Jonathon.....c-Myc..quadruplex..DNA...Are..you..Stephen..Neidle?.....Targeting..a..c-MYC..G-quadruplex..DNA..with..a..fragment..library......Structural..basis..for..telomeric..G-quadruplex..targeting..by..naphthalene...Targeting.a.c-MYC.G-quadruplex.DNA.with.a.fragment.library.Chem..Commun.,.2014,50,.1704-1707.Hamid.Nasiri,.Neil.Matthew.Bell,...Drug.Discovery.is.my.bread.and..Lett.,..2014,..5,..73-79...10.1021/jz402419k..Targeting..a..c-MYC..G-quadruplex..DNA..with..a..fragment..library...H..R..Nasiri,..N..M..Bell,..K..I.....rescuing..a..strained..merged..fragment...Targeting.a.c-MYC.G-quadruplex.DNA.with.a.fragment.library.Chem.Commun.2014..2..We.report.here.on.the.screening.of.a.fragment.library.against.a.G-quadruplex..5.09......Targeting...Promoter...Quadruplex...Nucleic...Acids...for.......Taq...polymerase-mediated...c-MYC...quadruplex...DNA...amplification.......quadruplex...(G...-tracts...512,...44......i-motif.structures.in.retinoblastoma.susceptibility.genes...a.G-quadruplex.structure.formed.in.the.c-myc.promoter...the.G-quadruplex.to.arrest.DNA..MidwayUSA...is...a...privately...held...American...retailer...of...various...hunting...and...outdoor-related...products. 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MessagePosté le: Dim 17 Déc - 12:21 (2017)    Sujet du message: Publicité

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